Celiac Disease Serum

About Celiac Disease Serum

Celiac Disease Serum for Autoimmune Enteropathy Research

Our Celiac Disease Serum is sourced from IRB-consented donors clinically diagnosed with celiac disease. Each sample is processed and frozen within 24 hours of collection to preserve autoantibodies, cytokines, and other circulating analytes. Serum is acellular, and is the standard matrix for celiac serology.

Celiac Disease Autoimmunity and Why Serum

Celiac disease is an autoimmune enteropathy triggered by dietary gluten in genetically susceptible individuals. It is unusual among autoimmune diseases in having a known environmental trigger and a well-characterised antigen:

• HLA restriction is near-absolute. Essentially all patients carry HLA-DQ2 or HLA-DQ8, which present deamidated gluten peptides to CD4+ T cells; HLA typing therefore has strong negative predictive value
• Transglutaminase 2 is both enzyme and autoantigen. It deamidates gliadin peptides to increase their DQ2/DQ8 affinity, and is itself the target of the disease-defining autoantibody response
• Serum autoantibodies are the diagnostic backbone: IgA anti-transglutaminase 2, IgA anti-endomysial antibodies, and antibodies to deamidated gliadin peptides
• Selective IgA deficiency is an important caveat — it is over-represented in celiac disease and causes false-negative IgA-based serology, so total IgA and IgG-class assays matter for cohort design
• Small-intestinal pathology is villous atrophy with crypt hyperplasia and intraepithelial lymphocytosis, graded on the Marsh classification; intraepithelial lymphocyte activation is IL-15 dependent
• Serology normalises on a gluten-free diet, which makes diet adherence and treatment status decisive variables when selecting donors for antibody-positive cohorts

Donor Stratification Available

• Diet status: gluten-containing diet versus established gluten-free diet
• Anti-transglutaminase 2 antibody status and titre category where clinically tested
• HLA-DQ2 and HLA-DQ8 genotype where available
• Biopsy-confirmed versus serology-based diagnosis, with Marsh grade where documented
• Symptom pattern, including classical gastrointestinal, extraintestinal, or asymptomatic presentation
• Coexisting autoimmune conditions such as type 1 diabetes or autoimmune thyroid disease
• Age at diagnosis, sex assigned at birth, and race/ethnicity
• Matched healthy controls available

Product Features

• Collected from clinically confirmed celiac disease donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• Standard and custom aliquot volumes available
• IRB-approved protocols with documented consent

De-identified Donor Data

• Diagnosis confirmation, including method of diagnosis where documented
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• Diet adherence, serology results, and comorbidities available on request

Applications

• Anti-transglutaminase 2, anti-endomysial, and deamidated gliadin peptide antibody assay development
• Diagnostic immunoassay validation, calibration, and reference panel construction
• IgA-deficient and IgG-class serology method development
• Autoantibody titre and diet-response longitudinal studies
• Cytokine and inflammatory mediator profiling
• Intestinal permeability and barrier marker research
• Proteomic and metabolomic biomarker discovery
• Therapeutic candidate screening and gluten-challenge study support

Other Celiac Disease Specimen Types

• Celiac Disease Plasma and Bulk Plasma — anticoagulated matrices and larger volumes
• Celiac Disease Whole Blood — fresh, for HLA typing and same-day cellular assays
• Celiac Disease PBMC and Leukopak — for gluten-specific T-cell and immunophenotyping work
• Pre-isolated subsets: CD4+ T cells, CD8+ T cells, CD19+ B cells, and CD56+ NK cells

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering and Customization

Celiac disease serum is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For healthy-donor controls and the full specimen range, see our human serum collection.