Multiple Sclerosis Whole Blood

About Multiple Sclerosis Whole Blood

Multiple Sclerosis Whole Blood for Neuroimmunology Research

Multiple Sclerosis Whole Blood is collected from IRB-consented donors with clinically confirmed multiple sclerosis (MS) and shipped same-day. Because the cellular compartment is intact, these fresh samples support immunophenotyping, functional assays, transcriptomics, and germline genotyping in neuroimmunology research.

MS Immunopathology and Why Whole Blood

Multiple sclerosis is an autoimmune, inflammatory demyelinating disease of the central nervous system. It is neither a dermatological condition nor a primary neurodegenerative one, although neurodegeneration follows the inflammatory injury:

• Autoimmune attack on myelin. Autoreactive CD4+ T cells of Th1 and Th17 phenotype, together with CD8+ T cells and B cells, cross the blood-brain barrier and drive focal demyelination, oligodendrocyte injury, and secondary axonal loss
• B cells are causally involved. The efficacy of anti-CD20 therapies established B cells as central to relapse biology, alongside the long-recognised intrathecal immunoglobulin synthesis seen as oligoclonal bands in cerebrospinal fluid
• Lymphocyte trafficking is a validated drug target — α4-integrin blockade and sphingosine-1-phosphate receptor modulation both act by restricting lymphocyte access to the CNS, making circulating lymphocyte composition a direct pharmacodynamic readout
• Risk architecture is well mapped: HLA-DRB1*15:01 is the dominant genetic risk allele, and Epstein-Barr virus infection, low vitamin D status, and smoking are established environmental associations
• Course subtypes differ mechanistically: relapsing-remitting MS is inflammation-dominant, while secondary and primary progressive forms feature progressive neurodegeneration with less prominent focal inflammation
• Why whole blood: fresh, unfractionated blood preserves granulocytes as well as mononuclear cells, permits same-day flow cytometry and stimulation assays, and is the preferred material for RNA stabilisation and germline HLA and risk-variant genotyping

Donor Stratification Available

• Course subtype: relapsing-remitting, secondary progressive, or primary progressive MS
• Disease activity: active relapse versus clinical remission
• Disability level where Expanded Disability Status Scale scores are documented
• Treatment status: treatment-naive, on anti-CD20 therapy, S1P modulators, natalizumab, or oral immunomodulators
• Disease duration and age at onset
• Age, sex assigned at birth, race/ethnicity, and vitamin D or smoking status where recorded
• Matched healthy controls available

Product Features

• Fresh whole blood from clinically diagnosed multiple sclerosis donors
• Custom tubes and anticoagulants available, including RNA stabilisation tubes
• Collected and shipped same-day for maximum viability
• Standard and custom volumes available
• Research Use Only (RUO)

De-identified Donor Data

• Confirmed multiple sclerosis diagnosis by physician or specialist, with subtype where documented
• Demographic details: age, sex assigned at birth, ethnicity
• Medical history including allergies and infectious disease status
• Disease-modifying therapy history and disability scores available on request

Applications

• Immunophenotyping of T-cell, B-cell, monocyte, and NK populations in MS
• Whole-blood stimulation and functional cytokine release assays
• Lymphocyte trafficking and disease-modifying therapy pharmacodynamic studies
• Whole-blood gene expression and transcriptomic analysis
• HLA typing and germline risk-variant genotyping
• Regulatory T-cell and B-cell subset characterisation
• Drug response and mechanism-of-action research
• Comparative studies across MS course subtypes and against matched controls

Other Multiple Sclerosis Specimen Types

• Multiple Sclerosis PBMC and Leukopak — cryopreserved and apheresis-derived cells
• Multiple Sclerosis Serum, Plasma, and Bulk Plasma — for soluble analytes including neurofilament light chain
• Multiple Sclerosis Cerebrospinal Fluid — the CNS-proximal compartment, for oligoclonal band and intrathecal immunoglobulin research
• Course-specific cohorts: Relapsing-Remitting MS Whole Blood and Secondary Progressive MS Whole Blood
• Pre-isolated subsets: CD4+ T cells, CD8+ T cells, CD19+ B cells, and CD56+ NK cells

Compliance and Quality Assurance

• IRB-approved protocols and electronic informed consent
• HIPAA-compliant data management
• Fast shipping with real-time tracking

Ordering and Customization

Multiple sclerosis whole blood is available in a range of standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For healthy-donor controls and the full specimen range, see our human whole blood collection.