Osteoarthritis Serum

About Osteoarthritis Serum

Osteoarthritis Serum for Degenerative Joint Disease Research

Our Osteoarthritis Serum is sourced from IRB-consented donors clinically diagnosed with osteoarthritis. Each sample is processed and frozen within 24 hours of collection to preserve cartilage and bone turnover products, inflammatory mediators, and other circulating proteins linked to osteoarthritis severity. Serum is acellular, so this product supports soluble-analyte work rather than cell-based assays.

Osteoarthritis Pathophysiology and Why Serum

Osteoarthritis is a degenerative disease of the whole joint. It is not rheumatoid arthritis, and autoantibody framing does not apply: rheumatoid factor and anti-citrullinated protein antibodies are not features of osteoarthritis and should not be expected in this cohort:

• Cartilage matrix breakdown is the central process, with progressive loss of type II collagen and aggrecan driven by matrix metalloproteinases and aggrecanases such as ADAMTS-4 and ADAMTS-5, outpacing chondrocyte repair
• Subchondral bone remodelling accompanies cartilage loss, producing sclerosis, bone marrow lesions, and osteophyte formation at the joint margins
• Inflammation is present but low-grade. Synovitis occurs and contributes to symptoms, but it is not the autoimmune synovitis of rheumatoid arthritis — the process is mechanically and metabolically driven
• Mechanical loading and obesity are major drivers, through both joint loading and systemic metabolic effects, which is why BMI is a meaningful stratification variable rather than an incidental demographic
• Serum research markers include CTX-II (a type II collagen degradation product), COMP (cartilage oligomeric matrix protein), and hyaluronan. These are research markers used in mechanistic and progression studies — they are not validated diagnostic tests for osteoarthritis
• Why serum: serum supports immunoassay of matrix turnover markers, multiplex inflammatory panels, proteomics, and metabolomics, with high aliquot counts and, where available, serial timepoints from the same donor

Donor Stratification Available

• Radiographic severity by Kellgren-Lawrence grade where imaging is documented
• Affected joint site: knee, hip, hand, spine, or multi-joint disease
• BMI category
• Symptom duration and pain severity where recorded
• Prior joint injury, surgery, or arthroplasty history
• Treatment status: analgesics, NSAIDs, or intra-articular injection
• Age, sex assigned at birth, and race/ethnicity
• Matched, age- and BMI-matched healthy controls available

Product Features

• Collected from clinically confirmed osteoarthritis donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• Standard and custom aliquot volumes available
• Paired synovial fluid from the same donor available on request
• IRB-approved protocols with documented consent

De-identified Donor Data

• Diagnosis confirmation, with affected joints where documented
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy and infectious disease history
• BMI, radiographic grade, and medication history available on request

Applications

• Cartilage degradation and matrix turnover marker research, including CTX-II and COMP
• Bone remodelling marker studies
• Structural progression biomarker discovery and qualification research
• Low-grade inflammatory mediator and cytokine profiling
• Metabolic and obesity-related pathway research in joint degeneration
• Proteomic and metabolomic biomarker discovery
• Immunoassay development and validation for matrix turnover analytes
• Differentiation of degenerative from inflammatory arthropathy in comparative cohorts

Other Osteoarthritis Specimen Types

• Osteoarthritis Synovial Fluid — the affected compartment itself, collected by arthrocentesis
• Osteoarthritis Plasma and Bulk Plasma — anticoagulated matrices and larger volumes
• Osteoarthritis Whole Blood — fresh, for cellular assays and genotyping
• Osteoarthritis PBMC and Leukopak — for cell-based work
• Rheumatoid Arthritis Serum — for an inflammatory, autoantibody-positive comparator cohort

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering and Customization

Osteoarthritis serum is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For healthy-donor controls and the full specimen range, see our human serum collection.