Osteoarthritis Serum
Osteoarthritis Serum — serum from clinically confirmed osteoarthritis donors, frozen within 24 hours. Ideal for analysing cartilage matrix turnover research markers such as CTX-II and COMP, bone remodelling markers, and low-grade inflammatory mediators. Osteoarthritis is degenerative, not autoimmune, so RF and ACPA framing does not apply. Kellgren-Lawrence grade, joint site, and BMI available for stratification.
Osteoarthritis Serum for Degenerative Joint Disease Research
Our Osteoarthritis Serum is sourced from IRB-consented donors clinically diagnosed with osteoarthritis. Each sample is processed and frozen within 24 hours of collection to preserve cartilage and bone turnover products, inflammatory mediators, and other circulating proteins linked to osteoarthritis severity. Serum is acellular, so this product supports soluble-analyte work rather than cell-based assays.
Osteoarthritis Pathophysiology and Why Serum
Osteoarthritis is a degenerative disease of the whole joint. It is not rheumatoid arthritis, and autoantibody framing does not apply: rheumatoid factor and anti-citrullinated protein antibodies are not features of osteoarthritis and should not be expected in this cohort:
- Cartilage matrix breakdown is the central process, with progressive loss of type II collagen and aggrecan driven by matrix metalloproteinases and aggrecanases such as ADAMTS-4 and ADAMTS-5, outpacing chondrocyte repair
- Subchondral bone remodelling accompanies cartilage loss, producing sclerosis, bone marrow lesions, and osteophyte formation at the joint margins
- Inflammation is present but low-grade. Synovitis occurs and contributes to symptoms, but it is not the autoimmune synovitis of rheumatoid arthritis — the process is mechanically and metabolically driven
- Mechanical loading and obesity are major drivers, through both joint loading and systemic metabolic effects, which is why BMI is a meaningful stratification variable rather than an incidental demographic
- Serum research markers include CTX-II (a type II collagen degradation product), COMP (cartilage oligomeric matrix protein), and hyaluronan. These are research markers used in mechanistic and progression studies — they are not validated diagnostic tests for osteoarthritis
- Why serum: serum supports immunoassay of matrix turnover markers, multiplex inflammatory panels, proteomics, and metabolomics, with high aliquot counts and, where available, serial timepoints from the same donor
Donor Stratification Available
- Radiographic severity by Kellgren-Lawrence grade where imaging is documented
- Affected joint site: knee, hip, hand, spine, or multi-joint disease
- BMI category
- Symptom duration and pain severity where recorded
- Prior joint injury, surgery, or arthroplasty history
- Treatment status: analgesics, NSAIDs, or intra-articular injection
- Age, sex assigned at birth, and race/ethnicity
- Matched, age- and BMI-matched healthy controls available
Product Features
- Collected from clinically confirmed osteoarthritis donors
- Processed and frozen within 24 hours of collection
- Research Use Only (RUO)
- Standard and custom aliquot volumes available
- Paired synovial fluid from the same donor available on request
- IRB-approved protocols with documented consent
De-identified Donor Data
- Diagnosis confirmation, with affected joints where documented
- Age, sex assigned at birth, and ethnicity
- Donor-reported allergy and infectious disease history
- BMI, radiographic grade, and medication history available on request
Applications
- Cartilage degradation and matrix turnover marker research, including CTX-II and COMP
- Bone remodelling marker studies
- Structural progression biomarker discovery and qualification research
- Low-grade inflammatory mediator and cytokine profiling
- Metabolic and obesity-related pathway research in joint degeneration
- Proteomic and metabolomic biomarker discovery
- Immunoassay development and validation for matrix turnover analytes
- Differentiation of degenerative from inflammatory arthropathy in comparative cohorts
Other Osteoarthritis Specimen Types
- Osteoarthritis Synovial Fluid — the affected compartment itself, collected by arthrocentesis
- Osteoarthritis Plasma and Bulk Plasma — anticoagulated matrices and larger volumes
- Osteoarthritis Whole Blood — fresh, for cellular assays and genotyping
- Osteoarthritis PBMC and Leukopak — for cell-based work
- Rheumatoid Arthritis Serum — for an inflammatory, autoantibody-positive comparator cohort
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11-compliant e-signatures
- Documentation support available for regulatory review
Ordering and Customization
Osteoarthritis serum is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For healthy-donor controls and the full specimen range, see our human serum collection.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.