Rheumatoid Arthritis Serum
Rheumatoid Arthritis Serum — human serum from IRB-consented donors with clinically confirmed rheumatoid arthritis, processed and frozen within 24 hours of collection. Serum is the reference matrix for the disease-defining autoantibodies ACPA and rheumatoid factor, and for CRP-based disease activity and IL-6 pathway work. Donors can be stratified by serology, DAS28 activity, and treatment class.
| Lot # | Condition | Volume | Race/Ethnicity | Age | Gender | Country of Collection | Medications | Vials | Price | Action |
|---|---|---|---|---|---|---|---|---|---|---|
| 77633 | Rheumatoid Arthritis | 1.0 ML | Hispanic/Latino | 60 | Female |
Anti-TNF
|
2 | $316.00 | ||
| 72661 | Rheumatoid Arthritis | 1.0 ML | Hispanic/Latino | 53 | Female |
Methotrexate 15mg PO Weekly, Folic Acid 1 mg POQD, Prednisone 5 mg, Famotidine 40mg POQD, Amlodipine 10 mgPOQD
|
15 | $316.00 | ||
| 75494 | Rheumatoid Arthritis | 1.0 ML | Caucasian | 71 | Female | United States |
humeral auto injector methotrexate 2.5mg QD hydroxychloroquine 200 mg QD amlodipine 2.5 mg QD Estring 2mg (7.5 mcg/24hour) Reclast infusion OTC vitamins
|
12 | $316.00 | |
| 75393 | Rheumatoid Arthritis | 1.0 ML | African American | 58 | Female | United States |
Methotrexate 2.5 mg takes 8 pills once a week Hydrocodone 10/325 PRN every 6 hours as need Amlodipine 10mg QD Amitriptyline 25mg QD Mehtocrabanol 500mg PRN
|
6 | $316.00 | |
| 74837 | Rheumatoid Arthritis | 1.0 ML | Caucasian | 44 | Female | United States |
hydroxychloroquine 200 mg QD fluvoxamine 50 mg x3 QD sulfasalazine 500 mg x 2 QD hydrochlorthaizide 12.5 mg QD nazomatone 500mg x2 QD xelgance 11mg QD errin 0.3 mg QD Rituximab 1000mg 1 per quarter
|
6 | $316.00 | |
| 74825 | Rheumatoid Arthritis | 1.0 ML | African American | 52 | Female | United States |
Ajovy QM clonidine 0.3 patch 1 patch per week dupixene 300 mg every other week cyops (insulin) PRN hydroxyzine 50 mg shot PRN Benadryl 50 mg shot PRN atrosan 0.6 mg PRN xalatin .0056 QPM methotrexate shot ozempic 0.5 mg QM sumatripton 6 mg QD traseenba 200 unit pin 20 units subdermal PRN zolair 300 mg QM byepti infusion Q4M
|
6 | $316.00 | |
| 74841 | Rheumatoid Arthritis | 1.0 ML | Other | 68 | Female | United States |
atenolol 5mg Qd
|
6 | $316.00 | |
| 74798 | Rheumatoid Arthritis | 1.0 ML | Caucasian | 67 | Female | United States |
Amlodopine/5mg/QD Remicade Hydrochlorothiazide Losartan/100/25/QD Celebrax/200mg/QD Aldactone/50mg/QD methotrexate injection 0.7ml QW asthma singular 10mg QD preventative inhaler 1160mcg 2 puffs BID iron 60mg QD omeprazole 40mg QD folic acid 1mg QD
|
6 | $316.00 | |
| 74827 | Rheumatoid Arthritis | 1.0 ML | Hispanic/Latino | 56 | Male | United States |
Enbrel 40 MG weekly metoprolol 50 mg twice day Amlodipine 10 Mg twice day Baby aspirin 1 daily
|
6 | $316.00 | |
| 70275 | Rheumatoid Arthritis | 1.0 ML | Hispanic/Latino | 62 | Female | United States |
Celecoxib 200 QD Alendronate Sodium QW Tylenol Arthritis 650 mg PRN Omeprazole 20 mg PRN Metformin 1000 mg BID Cymbalta 60 mg QD Plaquenil 400 mg QD Orencia 1 shot QW
|
1 | $316.00 |
Human Rheumatoid Arthritis Serum for Autoimmune and Autoantibody Research
Our Rheumatoid Arthritis Serum is sourced from IRB-consented donors clinically diagnosed with rheumatoid arthritis (RA). Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for autoantibody, proteomic and biomarker discovery studies. Rheumatoid arthritis is a genuinely autoimmune disease: tolerance to citrullinated self-proteins is lost, autoantibodies are produced, and the resulting synovial inflammation erodes cartilage and bone.
Why Serum for Rheumatoid Arthritis Research
- The two autoantibodies that define RA serologically — anti-citrullinated protein antibodies (ACPA, commonly measured as anti-CCP) and rheumatoid factor — are serum analytes and form part of the ACR/EULAR classification criteria. Serum is therefore the matrix in which RA is serologically defined.
- Autoantibody testing requires an anticoagulant-free matrix; citrate and EDTA carryover interferes with several immunoassay formats used for ACPA and rheumatoid factor quantification.
- ACPA can precede clinical arthritis by years, and its presence marks a more erosive disease course. Serum from serology-defined subgroups supports research on the seropositive versus seronegative divide, which is increasingly treated as two distinct disease entities.
- Anti-carbamylated protein antibodies and other anti-modified protein antibody families have been described in RA and broaden the autoantibody landscape available for interrogation in serum.
- CRP is embedded in the DAS28-CRP composite disease activity score, and IL-6 — the cytokine driving hepatic CRP production — is the direct target of IL-6 receptor blockade. Serum ties a validated clinical activity metric to a druggable pathway.
- Serum from RA donors can be paired with synovial fluid from the same disease to compare systemic autoantibody and cytokine levels against the inflamed joint compartment where the pathology sits.
Donor Stratification Available
- Serology: ACPA-positive, rheumatoid factor-positive, dual-positive, or seronegative RA; titres reported per lot where tested
- Disease activity by DAS28 or CDAI where recorded
- Treatment status: biologic-naive, on methotrexate or other conventional synthetic DMARD, on TNF inhibitor, on IL-6 receptor inhibitor, on JAK inhibitor, on rituximab or abatacept, or in washout
- Disease duration: early versus established RA
- Erosive versus non-erosive disease where radiographic status is reported
- Extra-articular involvement and comorbidity, including interstitial lung disease and secondary Sjögren’s syndrome
- Matched healthy controls available
Product Features
- Collected from clinically confirmed RA donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
- High-titre and serology-selected donors available on request
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and race/ethnicity
- Donor-reported allergy and infectious disease history
- Serology, disease activity and treatment history where available
- Additional RA-specific metadata available on request
Applications
- ACPA and rheumatoid factor assay development and validation
- Autoantibody epitope mapping and anti-modified protein antibody profiling
- Serum cytokine and protein profiling, including IL-6 and TNF pathway mediators
- CRP-based disease activity biomarker research
- Biomarker discovery for treatment response and radiographic progression
- Proteomic comparison of seropositive versus seronegative rheumatoid arthritis
- Diagnostic and companion assay development using disease-state serum as a clinically relevant matrix
- Therapeutic candidate screening and target validation in autoimmune disease
Other Rheumatoid Arthritis Specimen Types
- Rheumatoid Arthritis Plasma
- Rheumatoid Arthritis Whole Blood
- Rheumatoid Arthritis PBMC
- Rheumatoid Arthritis Leukopak
- Rheumatoid Arthritis Synovial Fluid
- Rheumatoid Arthritis Bulk Plasma
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Rheumatoid arthritis serum is available in standard and custom volumes. For pricing, availability, or to discuss a serology-stratified cohort, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse serum across all disease states and healthy donors, visit our human serum page.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
1 Answer
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
1 Answer
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
1 Answer
YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.