Rheumatoid Arthritis (RA) Serum
Powered by BiozAbout:Rheumatoid Arthritis Serum — human serum from consented donors with clinically confirmed rheumatoid arthritis, processed and frozen within 24 hours of collection. Serum is the reference matrix for the disease-defining autoantibodies ACPA and rheumatoid factor, and for CRP-based disease activity and IL-6 pathway work. Donors can be stratified by serology, DAS28 activity, and treatment class.
About Rheumatoid Arthritis (RA) Serum
Human Rheumatoid Arthritis Serum for Autoimmune and Autoantibody Research
Our Rheumatoid Arthritis Serum is sourced from IRB-consented donors clinically diagnosed with rheumatoid arthritis (RA). Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for autoantibody, proteomic and biomarker discovery studies. Rheumatoid arthritis is a genuinely autoimmune disease: tolerance to citrullinated self-proteins is lost, autoantibodies are produced, and the resulting synovial inflammation erodes cartilage and bone.
Why Serum for Rheumatoid Arthritis Research
- The two autoantibodies that define RA serologically — anti-citrullinated protein antibodies (ACPA, commonly measured as anti-CCP) and rheumatoid factor — are serum analytes and form part of the ACR/EULAR classification criteria. Serum is therefore the matrix in which RA is serologically defined.
- Autoantibody testing requires an anticoagulant-free matrix; citrate and EDTA carryover interferes with several immunoassay formats used for ACPA and rheumatoid factor quantification.
- ACPA can precede clinical arthritis by years, and its presence marks a more erosive disease course. Serum from serology-defined subgroups supports research on the seropositive versus seronegative divide, which is increasingly treated as two distinct disease entities.
- Anti-carbamylated protein antibodies and other anti-modified protein antibody families have been described in RA and broaden the autoantibody landscape available for interrogation in serum.
- CRP is embedded in the DAS28-CRP composite disease activity score, and IL-6 — the cytokine driving hepatic CRP production — is the direct target of IL-6 receptor blockade. Serum ties a validated clinical activity metric to a druggable pathway.
- Serum from RA donors can be paired with synovial fluid from the same disease to compare systemic autoantibody and cytokine levels against the inflamed joint compartment where the pathology sits.
Donor Stratification Available
- Serology: ACPA-positive, rheumatoid factor-positive, dual-positive, or seronegative RA; titres reported per lot where tested
- Disease activity by DAS28 or CDAI where recorded
- Treatment status: biologic-naive, on methotrexate or other conventional synthetic DMARD, on TNF inhibitor, on IL-6 receptor inhibitor, on JAK inhibitor, on rituximab or abatacept, or in washout
- Disease duration: early versus established RA
- Erosive versus non-erosive disease where radiographic status is reported
- Extra-articular involvement and comorbidity, including interstitial lung disease and secondary Sjögren’s syndrome
- Matched healthy controls available
Product Features
- Collected from clinically confirmed RA donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
- High-titre and serology-selected donors available on request
De-identified Donor Data
- Diagnosis confirmation
- Age, sex assigned at birth, and race/ethnicity
- Donor-reported allergy and infectious disease history
- Serology, disease activity and treatment history where available
- Additional RA-specific metadata available on request
Applications
- ACPA and rheumatoid factor assay development and validation
- Autoantibody epitope mapping and anti-modified protein antibody profiling
- Serum cytokine and protein profiling, including IL-6 and TNF pathway mediators
- CRP-based disease activity biomarker research
- Biomarker discovery for treatment response and radiographic progression
- Proteomic comparison of seropositive versus seronegative rheumatoid arthritis
- Diagnostic and companion assay development using disease-state serum as a clinically relevant matrix
- Therapeutic candidate screening and target validation in autoimmune disease
Other Rheumatoid Arthritis Specimen Types
- Rheumatoid Arthritis Plasma
- Rheumatoid Arthritis Whole Blood
- Rheumatoid Arthritis PBMC
- Rheumatoid Arthritis Leukopak
- Rheumatoid Arthritis Synovial Fluid
- Rheumatoid Arthritis Bulk Plasma
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Rheumatoid arthritis serum is available in standard and custom volumes. For pricing, availability, or to discuss a serology-stratified cohort, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse serum across all disease states and healthy donors, visit our human serum page.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Serum
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Pair with a Healthy Control
Match your Rheumatoid Arthritis (RA) Serum with normal donor samples for comparison
Healthy Serum
100 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.