Rheumatoid Arthritis Synovial Fluid

Rheumatoid Arthritis Synovial Fluid for Research

Rheumatoid Arthritis Synovial Fluid samples are collected from clinically confirmed rheumatoid arthritis donors by arthrocentesis. Buy or purchase RA synovial fluid in standard or custom volumes — pricing and current availability on request.

Why Synovial Fluid Is the Right Matrix for RA

Rheumatoid arthritis is a systemic autoimmune disease, but the destructive process is local: autoreactive immune infiltration of the synovium produces a hyperplastic, invasive pannus that erodes cartilage and bone. Synovial fluid sits directly in that compartment, so it carries the effector cells and mediators at concentrations often far above matched serum. In practice that means:

• Markedly elevated leukocyte counts, typically neutrophil-predominant in active inflammatory RA
• High local concentrations of TNF-α, IL-6, IL-1β, and IL-17
• Activated synovial fibroblasts, macrophages, and tissue-resident T and B cell populations
• Locally produced rheumatoid factor and anti-citrullinated protein antibodies (ACPA/anti-CCP)
• Matrix-degrading enzymes including MMP-3

Because peripheral blood dilutes all of this, synovial fluid frequently detects an effect that serum misses entirely — which is why paired synovial fluid and serum from the same donor is the strongest design for RA biomarker work.

Donor Stratification Available

• Serostatus — rheumatoid factor and anti-CCP positive or negative, where tested
• Disease activity — DAS28, CRP, and ESR values where recorded
• Disease duration — early vs established RA
• Affected joint — knee is most commonly aspirated; other joints on request
• Treatment status — treatment-naive, methotrexate, or biologic-treated (anti-TNF, anti-IL-6, JAK inhibitor)
• Paired specimens — matched serum, plasma, or PBMC from the same draw

Product Features

• Research Use Only (RUO), fresh or frozen synovial fluid
• Samples are frozen (if requested) within 4 hours of collection
• Clinically confirmed Rheumatoid Arthritis donors
• Collected by licensed clinicians under aseptic conditions
• Processed and shipped same-day where applicable
• Cell count and volume reported per sample
• IRB-approved protocols and electronic informed consent

De-identified Donor Data

• Verified diagnosis of Rheumatoid Arthritis
• Donor demographics: age, sex assigned at birth, race/ethnicity
• Self-reported medication history and affected joints
• Disease activity and clinical history available upon request

Applications

• Cellular and cytokine profiling of synovial fluid
• Synovial fibroblast and macrophage characterisation
• Tissue-resident immune cell phenotyping
• MMP and cartilage-degradation marker studies
• Transcriptomic, proteomic, and single-cell analysis
• Biomarker discovery and immunophenotyping
• Therapeutic response studies and drug target validation

Other Rheumatoid Arthritis Specimen Types

Matched material from RA donors is available as RA serum, plasma, whole blood, and leukopak. For other inflammatory arthropathies see psoriatic arthritis, gout, and osteoarthritis synovial fluid.

Quality and Compliance

• IRB-approved collections and SOP-driven processing
• 21 CFR Part 11-compliant electronic informed consent
• HIPAA-compliant donor data management

Ordering & Shipping

Rheumatoid Arthritis Synovial Fluid samples can be shipped ambient, refrigerated, or on dry ice. For pricing, orders outside the United States, or regulatory documentation, please contact learnmore@sanguinebio.com. For the full specimen range, see our human synovial fluid collection.