Systemic Lupus Erythematosus (SLE) PBMC

Systemic Lupus Erythematosus (SLE) PBMC for Research

Systemic Lupus Erythematosus Human PBMC products are sourced from donors clinically diagnosed with systemic lupus erythematosus (SLE) and processed under stringent conditions to support research. These cryopreserved peripheral blood mononuclear cells enable studies on immune dysregulation, cytokine response, and therapeutic development for SLE. Buy or purchase SLE PBMCs in cell counts from 5 million to 2 billion.

Why Donor PBMCs Matter in Lupus

SLE is a systemic autoimmune disease characterised by loss of tolerance to nuclear antigens, immune-complex deposition, and a pronounced type I interferon signature. That signature is measurable directly in circulating mononuclear cells, which is why patient PBMCs — rather than healthy cells stimulated in vitro — remain the reference material for interferon-driven research.

The compartment is broadly disturbed rather than confined to one cell type: expanded plasmablasts and autoreactive B cells, altered T follicular helper populations, impaired regulatory T cell function, low-density granulocytes primed for NET release, and monocytes skewed toward interferon-stimulated gene expression. Because SLE is also markedly heterogeneous and relapsing, disease activity and treatment status at the time of draw materially change what the cells show.

Donor Stratification Available

• Disease activity — SLEDAI score where recorded; active flare vs remission
• Autoantibody profile — ANA, anti-dsDNA, anti-Sm, anti-Ro/La, antiphospholipid where tested
• Complement — C3 and C4 levels where available
• Organ involvement — including lupus nephritis; see lupus nephritis PBMC
• Treatment status — treatment-naive, hydroxychloroquine, corticosteroid, mycophenolate, or biologic-treated donors
• Longitudinal draws — serial time points from the same donor, including across a flare, where available
• Matched healthy controls available

Product Features

• Research Use Only (RUO), cryopreserved PBMCs
• Clinically confirmed SLE donors
• Available in cell counts ranging from 5 million to 2 billion
• Processed within 24 hours of collection
• Stored using CryoStor® CS10 freezing media
• IRB-approved protocols and electronic informed consent
• Screen LeukoLot™ available prior to bulk orders

De-identified Donor Data

• Confirmed SLE diagnosis by physician or specialist
• Demographic details: age, sex assigned at birth, ethnicity
• Medical history including allergies and infectious disease status
• Explore our SLE Donor Network

Applications

• Type I interferon signature and interferon-stimulated gene analysis
• B cell and plasmablast phenotyping, including autoreactive repertoires
• Regulatory T cell and Tfh characterisation
• Biomarker discovery and validation
• Drug screening and therapeutic development, including CAR-T and B-cell-directed approaches
• Immune pathway analysis in SLE pathophysiology
• Transcriptomic, proteomic, and single-cell profiling

Other SLE Specimen Types

Matched material from SLE donors is available as SLE plasma, serum, whole blood, leukopak, and bulk apheresis plasma. Isolated subsets include CD4+ and CD8+ T cells, CD19+ B cells, and CD56+ NK cells.

Quality and Compliance

• IRB-approved collections and protocols
• 21 CFR Part 11 – compliant e-consent system
• HIPAA-compliant donor data protection

Ordering & Shipping

Systemic Lupus Erythematosus SLE Human PBMC samples are shipped on dry ice and available in custom aliquots. For international orders or regulatory requirements, please contact learnmore@sanguinebio.com to confirm documentation and compliance needs. For the full specimen range, see our human PBMCs collection.