Systemic Lupus Erythematosus (SLE) PBMC
Powered by BiozAbout:Systemic Lupus Erythematosus PBMC samples are collected from clinically confirmed Systemic Lupus Erythematosus (SLE) donors and cryopreserved. These PBMCs are ideal for examining immune dysregulation in lupus.
About Systemic Lupus Erythematosus (SLE) PBMC
Systemic Lupus Erythematosus (SLE) PBMC for Research
Systemic Lupus Erythematosus Human PBMC products are sourced from donors clinically diagnosed with systemic lupus erythematosus (SLE) and processed under stringent conditions to support research. These cryopreserved peripheral blood mononuclear cells enable studies on immune dysregulation, cytokine response, and therapeutic development for SLE. Buy or purchase SLE PBMCs in cell counts from 5 million to 2 billion.
Why Donor PBMCs Matter in Lupus
SLE is a systemic autoimmune disease characterised by loss of tolerance to nuclear antigens, immune-complex deposition, and a pronounced type I interferon signature. That signature is measurable directly in circulating mononuclear cells, which is why patient PBMCs — rather than healthy cells stimulated in vitro — remain the reference material for interferon-driven research.
The compartment is broadly disturbed rather than confined to one cell type: expanded plasmablasts and autoreactive B cells, altered T follicular helper populations, impaired regulatory T cell function, low-density granulocytes primed for NET release, and monocytes skewed toward interferon-stimulated gene expression. Because SLE is also markedly heterogeneous and relapsing, disease activity and treatment status at the time of draw materially change what the cells show.
Donor Stratification Available
- Disease activity — SLEDAI score where recorded; active flare vs remission
- Autoantibody profile — ANA, anti-dsDNA, anti-Sm, anti-Ro/La, antiphospholipid where tested
- Complement — C3 and C4 levels where available
- Organ involvement — including lupus nephritis; see lupus nephritis PBMC
- Treatment status — treatment-naive, hydroxychloroquine, corticosteroid, mycophenolate, or biologic-treated donors
- Longitudinal draws — serial time points from the same donor, including across a flare, where available
- Matched healthy controls available
Product Features
- Research Use Only (RUO), cryopreserved PBMCs
- Clinically confirmed SLE donors
- Available in cell counts ranging from 5 million to 2 billion
- Processed within 24 hours of collection
- Stored using CryoStor® CS10 freezing media
- IRB-approved protocols and electronic informed consent
- Screen LeukoLot™ available prior to bulk orders
De-identified Donor Data
- Confirmed SLE diagnosis by physician or specialist
- Demographic details: age, sex assigned at birth, ethnicity
- Medical history including allergies and infectious disease status
- Explore our SLE Donor Network
Applications
- Type I interferon signature and interferon-stimulated gene analysis
- B cell and plasmablast phenotyping, including autoreactive repertoires
- Regulatory T cell and Tfh characterisation
- Biomarker discovery and validation
- Drug screening and therapeutic development, including CAR-T and B-cell-directed approaches
- Immune pathway analysis in SLE pathophysiology
- Transcriptomic, proteomic, and single-cell profiling
Other SLE Specimen Types
Matched material from SLE donors is available as SLE plasma, serum, whole blood, leukopak, and bulk apheresis plasma. Isolated subsets include CD4+ and CD8+ T cells, CD19+ B cells, and CD56+ NK cells.
Quality and Compliance
- IRB-approved collections and protocols
- 21 CFR Part 11 – compliant e-consent system
- HIPAA-compliant donor data protection
Ordering & Shipping
Systemic Lupus Erythematosus SLE Human PBMC samples are shipped on dry ice and available in custom aliquots. For international orders or regulatory requirements, please contact learnmore@sanguinebio.com to confirm documentation and compliance needs. For the full specimen range, see our human PBMCs collection.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human PBMC are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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PBMC Isolation from Whole Blood
Standard operating procedure for isolating peripheral blood mononuclear cells from whole blood using density-gradient separation.
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Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Choosing the Right PBMC Configuration
Reference guide comparing PBMC formats, cryopreservation states, and study-fit recommendations for your application.
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Thawing Cryopreserved PBMC
Validated thawing protocol to recover viable cryopreserved PBMCs while minimizing activation and loss of function.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
PBMC
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Pair with a Healthy Control
Match your Systemic Lupus Erythematosus (SLE) PBMC with normal donor samples for comparison
Healthy PBMC
806 In Stock View InventoryNeed a custom PBMC cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.