Systemic Lupus Erythematosus Whole Blood

About Systemic Lupus Erythematosus Whole Blood

Systemic Lupus Erythematosus Whole Blood for Autoimmune and Rheumatology Research

Systemic Lupus Erythematosus Whole Blood is collected from IRB-consented donors with a clinically confirmed SLE diagnosis. Fresh whole blood is collected and shipped same-day, with custom anticoagulants and collection tubes available. Research Use Only (RUO).

Disease Immunology and Why Whole Blood

• SLE is a multi-system autoimmune disease characterized by loss of tolerance to nuclear antigens, with antinuclear antibodies and anti-double-stranded DNA antibodies as defining serology; anti-Sm and anti-Ro/SSA are also common.
• Nucleic acid-containing immune complexes are internalized and signal through endosomal nucleic acid sensors, driving type I interferon production. The resulting interferon transcriptional signature is one of the most reproducible molecular features of the disease and is the basis for interferon receptor-directed therapy.
• B cell survival factor signaling is a validated therapeutic axis, and complement consumption with low C3 and C4 accompanies active disease, so both cellular and soluble readouts are informative.
• Neutrophil biology contributes as well, including release of neutrophil extracellular traps that expose nuclear antigen. Neutrophils are lost when PBMCs are isolated, which is a specific argument for whole blood.
• Whole blood preserves all leukocyte populations plus plasma in a single specimen, supporting whole-blood transcriptomics, intracellular signaling and phospho-flow work, and DNA extraction from the same donor draw.
• SLE is clinically heterogeneous, ranging from predominantly cutaneous and articular disease to severe renal involvement, so organ-annotated donors are essential for interpretable results.

Donor Stratification Available

• Autoantibody profile where documented: ANA titer, anti-dsDNA, anti-Sm, anti-Ro/SSA, antiphospholipid antibodies
• Organ involvement: renal, cutaneous, articular, hematologic, neuropsychiatric
• Disease activity at collection: active flare versus quiescent or low disease activity
• Complement status where documented, including low C3 or C4
• Treatment status: hydroxychloroquine, corticosteroid, conventional immunosuppressant, biologic therapy, or treatment-naive
• Disease duration, age, sex, and self-reported race/ethnicity
• Matched healthy controls available

Product Features

• Fresh whole blood from clinically diagnosed SLE donors
• Custom anticoagulants and collection tubes available, including RNA-stabilizing tubes on request
• Same-day collection and shipment
• Custom volumes available
• IRB-approved protocols and electronic informed consent
• Research Use Only (RUO)

De-identified Donor Data

• Physician-confirmed diagnosis, including ANA and anti-dsDNA status and organ involvement where available
• Demographics: age, sex assigned at birth, ethnicity
• Relevant medical and treatment history
• Disease activity assessment at collection where available

Applications

• ANA and anti-dsDNA autoantibody research
• Type I interferon signature and whole-blood transcriptomic analysis
• Whole-blood immunophenotyping including granulocyte populations
• Neutrophil function and neutrophil extracellular trap studies
• Complement activation and immune complex research
• Intracellular signaling and phospho-flow assays
• Biologic and small-molecule therapy response research
• Genomic DNA extraction for genetic association studies

Other Systemic Lupus Erythematosus Specimen Types

• Systemic Lupus Erythematosus Plasma
• Systemic Lupus Erythematosus Serum
• Systemic Lupus Erythematosus PBMC
• Systemic Lupus Erythematosus Leukopak

Looking for a specific lupus manifestation? See our Lupus Nephritis, Cutaneous Lupus Erythematosus, and Discoid Lupus Erythematosus Whole Blood products.

Compliance and Quality Assurance

• IRB-approved protocols and electronic informed consent
• HIPAA-compliant donor data handling
• 21 CFR Part 11-compliant e-signatures

Ordering & Customization

SLE Whole Blood is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, email learnmore@sanguinebio.com. To browse all matrices and disease states, visit our human whole blood page.