Systemic Lupus Erythematosus Whole Blood
Fresh whole blood from IRB-consented donors with confirmed systemic lupus erythematosus (SLE), shipped same-day. Useful for ANA and anti-dsDNA autoantibody work, type I interferon signature and whole-blood transcriptomics, neutrophil and NET studies, and complement research. Stratification by organ involvement, autoantibody profile, and disease activity.
Systemic Lupus Erythematosus Whole Blood for Autoimmune and Rheumatology Research
Systemic Lupus Erythematosus Whole Blood is collected from IRB-consented donors with a clinically confirmed SLE diagnosis. Fresh whole blood is collected and shipped same-day, with custom anticoagulants and collection tubes available. Research Use Only (RUO).
Disease Immunology and Why Whole Blood
- SLE is a multi-system autoimmune disease characterized by loss of tolerance to nuclear antigens, with antinuclear antibodies and anti-double-stranded DNA antibodies as defining serology; anti-Sm and anti-Ro/SSA are also common.
- Nucleic acid-containing immune complexes are internalized and signal through endosomal nucleic acid sensors, driving type I interferon production. The resulting interferon transcriptional signature is one of the most reproducible molecular features of the disease and is the basis for interferon receptor-directed therapy.
- B cell survival factor signaling is a validated therapeutic axis, and complement consumption with low C3 and C4 accompanies active disease, so both cellular and soluble readouts are informative.
- Neutrophil biology contributes as well, including release of neutrophil extracellular traps that expose nuclear antigen. Neutrophils are lost when PBMCs are isolated, which is a specific argument for whole blood.
- Whole blood preserves all leukocyte populations plus plasma in a single specimen, supporting whole-blood transcriptomics, intracellular signaling and phospho-flow work, and DNA extraction from the same donor draw.
- SLE is clinically heterogeneous, ranging from predominantly cutaneous and articular disease to severe renal involvement, so organ-annotated donors are essential for interpretable results.
Donor Stratification Available
- Autoantibody profile where documented: ANA titer, anti-dsDNA, anti-Sm, anti-Ro/SSA, antiphospholipid antibodies
- Organ involvement: renal, cutaneous, articular, hematologic, neuropsychiatric
- Disease activity at collection: active flare versus quiescent or low disease activity
- Complement status where documented, including low C3 or C4
- Treatment status: hydroxychloroquine, corticosteroid, conventional immunosuppressant, biologic therapy, or treatment-naive
- Disease duration, age, sex, and self-reported race/ethnicity
- Matched healthy controls available
Product Features
- Fresh whole blood from clinically diagnosed SLE donors
- Custom anticoagulants and collection tubes available, including RNA-stabilizing tubes on request
- Same-day collection and shipment
- Custom volumes available
- IRB-approved protocols and electronic informed consent
- Research Use Only (RUO)
De-identified Donor Data
- Physician-confirmed diagnosis, including ANA and anti-dsDNA status and organ involvement where available
- Demographics: age, sex assigned at birth, ethnicity
- Relevant medical and treatment history
- Disease activity assessment at collection where available
Applications
- ANA and anti-dsDNA autoantibody research
- Type I interferon signature and whole-blood transcriptomic analysis
- Whole-blood immunophenotyping including granulocyte populations
- Neutrophil function and neutrophil extracellular trap studies
- Complement activation and immune complex research
- Intracellular signaling and phospho-flow assays
- Biologic and small-molecule therapy response research
- Genomic DNA extraction for genetic association studies
Other Systemic Lupus Erythematosus Specimen Types
- Systemic Lupus Erythematosus Plasma
- Systemic Lupus Erythematosus Serum
- Systemic Lupus Erythematosus PBMC
- Systemic Lupus Erythematosus Leukopak
Looking for a specific lupus manifestation? See our Lupus Nephritis, Cutaneous Lupus Erythematosus, and Discoid Lupus Erythematosus Whole Blood products.
Compliance and Quality Assurance
- IRB-approved protocols and electronic informed consent
- HIPAA-compliant donor data handling
- 21 CFR Part 11-compliant e-signatures
Ordering & Customization
SLE Whole Blood is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, email learnmore@sanguinebio.com. To browse all matrices and disease states, visit our human whole blood page.
Whole Blood
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom Whole Blood cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.