Hidradenitis Suppurativa Plasma

Hidradenitis Suppurativa Plasma for Immune-Mediated Inflammatory Disease Research

Hidradenitis Suppurativa Plasma is collected from IRB-consented donors clinically diagnosed with hidradenitis suppurativa (HS) and processed within one day of collection to preserve key analytes such as cytokines, proteins and metabolites. HS is a chronic immune-mediated inflammatory skin disease of the hair follicle and adjacent apocrine gland-bearing skin, in which follicular occlusion and rupture trigger a deep, destructive inflammatory response producing painful nodules, abscesses, draining tunnels and scarring. This human plasma supports inflammatory pathway research and biomarker discovery.

Follicular Occlusion, Innate Inflammation and Why Plasma

• The initiating event is follicular occlusion and rupture, which releases follicular contents into the dermis and provokes an intense neutrophil- and macrophage-rich inflammatory response. HS is immune-mediated and inflammatory, not autoimmune.
• Lesional and circulating cytokine profiles implicate TNF-alpha, IL-17 and IL-1 family signalling, which is the rationale for the TNF and IL-17 pathway biologics now used in HS.
• HS carries a substantial systemic inflammatory burden, with elevated acute-phase reactants including CRP frequently observed and correlating with disease severity.
• Secondary bacterial colonisation and biofilm formation within tunnels contribute to the inflammatory cycle without HS being a primary infectious disease.
• HS is strongly associated with metabolic comorbidity, including obesity and metabolic syndrome, and with other immune-mediated conditions such as inflammatory bowel disease — making plasma a useful matrix for studying shared systemic inflammation.
• Plasma is acellular. It supports cytokine and acute-phase protein immunoassay, proteomic and metabolomic profiling, but not flow cytometry or other cell-based assays.

Donor Stratification Available

• Hurley stage I, II or III as documented
• Anatomical distribution and number of affected sites where documented
• Treatment status: topical or oral antibiotics, TNF or IL-17 pathway biologic, retinoid, or treatment-naive
• Presence of metabolic comorbidity, including obesity, metabolic syndrome or type 2 diabetes
• Associated immune-mediated comorbidity such as inflammatory bowel disease or spondyloarthritis
• Smoking status where documented
• Matched healthy controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed HS donors
• Processed within one day of collection
• Anticoagulant selection available on request
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified HS diagnosis, with Hurley stage where documented
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Additional hidradenitis suppurativa-specific metadata available

Applications

• TNF-alpha, IL-17 and IL-1 family cytokine profiling
• Acute-phase reactant and systemic inflammatory burden characterisation
• Severity-correlated biomarker discovery and validation
• Biologic therapy response and pharmacodynamic biomarker research
• Plasma proteomic and metabolomic discovery studies
• Neutrophil-associated mediator and protease profiling
• Shared-pathway research across immune-mediated inflammatory diseases
• Metabolic comorbidity and systemic inflammation crossover studies

Other Hidradenitis Suppurativa Specimen Types

• Hidradenitis Suppurativa Bulk Plasma
• Hidradenitis Suppurativa Serum
• Hidradenitis Suppurativa Whole Blood
• Hidradenitis Suppurativa PBMC
• Hidradenitis Suppurativa Leukopak
• Hidradenitis Suppurativa Skin Punch Biopsy

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Hidradenitis suppurativa plasma is available in standard and custom volumes. For pricing, current availability, international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse donor cohorts across our full inventory, visit our human plasma page.