Hidradenitis Suppurativa Serum
Powered by BiozAbout:Hidradenitis Suppurativa Serum from consented donors with clinically confirmed HS, a chronic immune-mediated inflammatory skin disease of follicular occlusion. Ideal for profiling inflammatory mediators, acute-phase reactants and severity-correlated biomarkers, and for TNF and IL-17 pathway research. Hurley stage stratification available.
About Hidradenitis Suppurativa Serum
Hidradenitis Suppurativa Serum for Immune-Mediated Inflammatory Disease Research
Our Hidradenitis Suppurativa Serum is sourced from IRB-consented donors clinically diagnosed with hidradenitis suppurativa (HS). Each sample is processed and frozen within 24 hours of collection to preserve cytokines, acute-phase proteins and other labile analytes. HS is a chronic immune-mediated inflammatory skin disease of the hair follicle and adjacent apocrine gland-bearing skin, in which follicular occlusion and rupture trigger a deep, destructive inflammatory response producing painful nodules, abscesses, draining tunnels and scarring.
Follicular Occlusion, Innate Inflammation and Why Serum
- The initiating event is follicular occlusion and rupture, which releases follicular contents into the dermis and provokes an intense neutrophil- and macrophage-rich inflammatory response. HS is immune-mediated and inflammatory, not autoimmune.
- Lesional and circulating cytokine profiles implicate TNF-alpha, IL-17 and IL-1 family signalling, which is the rationale for the TNF and IL-17 pathway biologics now used in HS.
- HS carries a substantial systemic inflammatory burden, with elevated acute-phase reactants including CRP frequently observed and correlating with disease severity. Serum is a standard matrix for CRP and routine inflammatory chemistry.
- Secondary bacterial colonisation and biofilm formation within tunnels contribute to the inflammatory cycle without HS being a primary infectious disease.
- HS is strongly associated with metabolic comorbidity, including obesity and metabolic syndrome, and with other immune-mediated conditions such as inflammatory bowel disease — making serum a useful matrix for studying shared systemic inflammation.
- Serum is acellular. It supports cytokine and acute-phase protein immunoassay, proteomic and metabolomic profiling, but not flow cytometry or other cell-based assays.
Donor Stratification Available
- Hurley stage I, II or III as documented
- Anatomical distribution and number of affected sites where documented
- Treatment status: topical or oral antibiotics, TNF or IL-17 pathway biologic, retinoid, or treatment-naive
- Presence of metabolic comorbidity, including obesity, metabolic syndrome or type 2 diabetes
- Associated immune-mediated comorbidity such as inflammatory bowel disease or spondyloarthritis
- Smoking status where documented
- Matched healthy controls available
Product Features
- Collected from clinically confirmed HS donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Custom aliquot volumes available upon request
De-identified Donor Data
- Diagnosis confirmation, with Hurley stage where documented
- Age, sex assigned at birth, and race/ethnicity
- Donor-reported medications, allergy and infectious disease history, and comorbidities
- Additional hidradenitis suppurativa-specific metadata available
Applications
- TNF-alpha, IL-17 and IL-1 family cytokine profiling
- Acute-phase reactant and systemic inflammatory burden characterisation
- Severity-correlated biomarker discovery and validation
- Biologic therapy response and pharmacodynamic biomarker research
- Serum proteomic and metabolomic discovery studies
- Neutrophil-associated mediator and protease profiling
- Shared-pathway research across immune-mediated inflammatory diseases
- Metabolic comorbidity and systemic inflammation crossover studies
Other Hidradenitis Suppurativa Specimen Types
- Hidradenitis Suppurativa Plasma
- Hidradenitis Suppurativa Bulk Plasma
- Hidradenitis Suppurativa Whole Blood
- Hidradenitis Suppurativa PBMC
- Hidradenitis Suppurativa Leukopak
- Hidradenitis Suppurativa Skin Punch Biopsy
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Hidradenitis suppurativa serum is available in standard and custom volumes. For pricing, current availability, international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse donor cohorts across our full inventory, visit our human serum page.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), Serum
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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100 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.