Human Immunodeficiency Virus HIV CD56+ NK Cells

HIV CD56+ NK Cells for Viral Immune Surveillance Research

HIV CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with Human Immunodeficiency Virus (HIV). These CD56+ CD3− natural killer cells reflect the innate immune alterations of chronic HIV infection and support studies of immune surveillance, cytotoxicity, and antibody-dependent effector function.

NK Cells in HIV Infection

NK cells sit at the front line of innate antiviral defence, and HIV reshapes the compartment in specific, well-characterised ways:

• Expansion of an anergic CD56-negative subset — a dysfunctional population that accumulates in viremic donors and only partially resolves on therapy
• Impaired cytotoxicity and reduced degranulation, with altered activating and inhibitory receptor balance
• ADCC (antibody-dependent cellular cytotoxicity) — an effector mechanism strongly implicated as a correlate of protection in HIV vaccine trials, making donor NK cells directly relevant to vaccine research
• KIR/HLA interactions — specific combinations such as KIR3DS1 with HLA-Bw4 associate with slower disease progression, so genotype-stratified NK cells support host-genetics work
• Adaptive or memory-like NK expansion, particularly in CMV-coinfected donors

Donor Stratification Available

• Viral load and CD4+ count where tested
• Treatment status — viremic, or suppressed on ART with duration
• KIR and HLA genotype where sequenced
• CMV serostatus — relevant to adaptive NK subset frequency
• Elite controllers — available as custom collections
• Matched seronegative controls available

Product Features

• Research Use Only (RUO), CD56+ enriched NK cells
• Isolated from clinically diagnosed HIV-positive donors
• High viability and enrichment
• Cryopreserved in CryoStor® CS10 media
• Processed within 24 hours of collection
• Flow cytometry purity and viability data per lot
• Ethically sourced with IRB approval and HIPAA compliance
• Biosafety-compliant handling and shipping

De-identified Donor Data

• Confirmed diagnosis of HIV
• Demographics: age, sex assigned at birth, race/ethnicity
• Self-reported clinical history and medication use

Applications

• NK cell phenotype and function studies in HIV
• ADCC assays and vaccine correlate-of-protection research
• Cytotoxicity, degranulation, and immune exhaustion assays
• KIR/HLA host genetics research
• Adaptive and memory-like NK characterisation
• Single-cell analysis and receptor repertoire profiling
• Disease mechanism studies and biomarker identification
• Preclinical immunotherapy development, including CAR-NK approaches

Other HIV Specimen Types

Matched material is available as HIV CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, PBMC, and leukopak.

Compliance and Quality Assurance

• IRB-approved collection and 21 CFR Part 11–compliant e-consent
• Standardized processing and quality protocols
• HIPAA-compliant data handling

Ordering & Customization

HIV CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.