Human Immunodeficiency Virus HIV CD56+ NK Cells

HIV CD56+ NK Cells for Viral Immune Surveillance Research

HIV CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with Human Immunodeficiency Virus (HIV). These CD56+ CD3− natural killer cells reflect the innate immune alterations of chronic HIV infection and support studies of immune surveillance, cytotoxicity, and antibody-dependent effector function.

NK Cells in HIV Infection

NK cells sit at the front line of innate antiviral defence, and HIV reshapes the compartment in specific, well-characterised ways:

  • Expansion of an anergic CD56-negative subset — a dysfunctional population that accumulates in viremic donors and only partially resolves on therapy
  • Impaired cytotoxicity and reduced degranulation, with altered activating and inhibitory receptor balance
  • ADCC (antibody-dependent cellular cytotoxicity) — an effector mechanism strongly implicated as a correlate of protection in HIV vaccine trials, making donor NK cells directly relevant to vaccine research
  • KIR/HLA interactions — specific combinations such as KIR3DS1 with HLA-Bw4 associate with slower disease progression, so genotype-stratified NK cells support host-genetics work
  • Adaptive or memory-like NK expansion, particularly in CMV-coinfected donors

Donor Stratification Available

  • Viral load and CD4+ count where tested
  • Treatment status — viremic, or suppressed on ART with duration
  • KIR and HLA genotype where sequenced
  • CMV serostatus — relevant to adaptive NK subset frequency
  • Elite controllers — available as custom collections
  • Matched seronegative controls available

Product Features

  • Research Use Only (RUO), CD56+ enriched NK cells
  • Isolated from clinically diagnosed HIV-positive donors
  • High viability and enrichment
  • Cryopreserved in CryoStor® CS10 media
  • Processed within 24 hours of collection
  • Flow cytometry purity and viability data per lot
  • Ethically sourced with IRB approval and HIPAA compliance
  • Biosafety-compliant handling and shipping

De-identified Donor Data

  • Confirmed diagnosis of HIV
  • Demographics: age, sex assigned at birth, race/ethnicity
  • Self-reported clinical history and medication use

Applications

  • NK cell phenotype and function studies in HIV
  • ADCC assays and vaccine correlate-of-protection research
  • Cytotoxicity, degranulation, and immune exhaustion assays
  • KIR/HLA host genetics research
  • Adaptive and memory-like NK characterisation
  • Single-cell analysis and receptor repertoire profiling
  • Disease mechanism studies and biomarker identification
  • Preclinical immunotherapy development, including CAR-NK approaches

Other HIV Specimen Types

Matched material is available as HIV CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, PBMC, and leukopak.

Compliance and Quality Assurance

  • IRB-approved collection and 21 CFR Part 11–compliant e-consent
  • Standardized processing and quality protocols
  • HIPAA-compliant data handling

Ordering & Customization

HIV CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.

Protocols & Documentation

  • Immune Cell Isolation

    Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.

    Download
  • Informed Consent Form (ICF)

    Available upon request — confirms donor consent for research use and downstream commercialization.

Frequently Asked Questions

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Are samples IRB approved?

1 Answer

YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.

YES – all our products are research use only (RUO).

Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.

Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.

Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.

Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.

YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.

Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.

YES – Unique donors can be specified and guaranteed based on your requirements.

For information about sample quality, please see: Quality and Compliance

YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.

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Need a custom CD56+ NK Cells cohort?

Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.

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