Human Immunodeficiency Virus HIV CD56+ NK Cells
About:HIV CD56+ NK Cells are derived from consented HIV-positive donors. Useful for evaluating NK cell exhaustion, impaired cytotoxicity, ADCC, KIR/HLA interactions, and chronic viral immune surveillance.
About Human Immunodeficiency Virus HIV CD56+ NK Cells
HIV CD56+ NK Cells for Viral Immune Surveillance Research
HIV CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with Human Immunodeficiency Virus (HIV). These CD56+ CD3− natural killer cells reflect the innate immune alterations of chronic HIV infection and support studies of immune surveillance, cytotoxicity, and antibody-dependent effector function.
NK Cells in HIV Infection
NK cells sit at the front line of innate antiviral defence, and HIV reshapes the compartment in specific, well-characterised ways:
- Expansion of an anergic CD56-negative subset — a dysfunctional population that accumulates in viremic donors and only partially resolves on therapy
- Impaired cytotoxicity and reduced degranulation, with altered activating and inhibitory receptor balance
- ADCC (antibody-dependent cellular cytotoxicity) — an effector mechanism strongly implicated as a correlate of protection in HIV vaccine trials, making donor NK cells directly relevant to vaccine research
- KIR/HLA interactions — specific combinations such as KIR3DS1 with HLA-Bw4 associate with slower disease progression, so genotype-stratified NK cells support host-genetics work
- Adaptive or memory-like NK expansion, particularly in CMV-coinfected donors
Donor Stratification Available
- Viral load and CD4+ count where tested
- Treatment status — viremic, or suppressed on ART with duration
- KIR and HLA genotype where sequenced
- CMV serostatus — relevant to adaptive NK subset frequency
- Elite controllers — available as custom collections
- Matched seronegative controls available
Product Features
- Research Use Only (RUO), CD56+ enriched NK cells
- Isolated from clinically diagnosed HIV-positive donors
- High viability and enrichment
- Cryopreserved in CryoStor® CS10 media
- Processed within 24 hours of collection
- Flow cytometry purity and viability data per lot
- Ethically sourced with IRB approval and HIPAA compliance
- Biosafety-compliant handling and shipping
De-identified Donor Data
- Confirmed diagnosis of HIV
- Demographics: age, sex assigned at birth, race/ethnicity
- Self-reported clinical history and medication use
Applications
- NK cell phenotype and function studies in HIV
- ADCC assays and vaccine correlate-of-protection research
- Cytotoxicity, degranulation, and immune exhaustion assays
- KIR/HLA host genetics research
- Adaptive and memory-like NK characterisation
- Single-cell analysis and receptor repertoire profiling
- Disease mechanism studies and biomarker identification
- Preclinical immunotherapy development, including CAR-NK approaches
Other HIV Specimen Types
Matched material is available as HIV CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, PBMC, and leukopak.
Compliance and Quality Assurance
- IRB-approved collection and 21 CFR Part 11–compliant e-consent
- Standardized processing and quality protocols
- HIPAA-compliant data handling
Ordering & Customization
HIV CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.
Applications
- Immunology and translational research
- Biomarker discovery and validation
- Drug screening and assay development
- Vaccine and infectious disease research
Product Features
- Research Use Only (RUO), CD56+ NK Cells
- Sourced from screened, consented donors
- Processed under validated SOPs
- QC tested for purity, viability, and sterility
- Processed within 24 hours of collection
- IRB-approved protocols with electronic informed consent
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human CD56+ NK Cells are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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Match your Human Immunodeficiency Virus HIV CD56+ NK Cells with normal donor samples for comparison
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View InventoryNeed a custom CD56+ NK Cells cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.