Human Immunodeficiency Virus HIV CD56+ NK Cells
HIV CD56+ NK Cells are derived from IRB-consented HIV-positive donors. Useful for evaluating NK cell exhaustion, impaired cytotoxicity, ADCC, KIR/HLA interactions, and chronic viral immune surveillance.
HIV CD56+ NK Cells for Viral Immune Surveillance Research
HIV CD56+ NK Cells are cryopreserved from peripheral blood of IRB-consented adult donors diagnosed with Human Immunodeficiency Virus (HIV). These CD56+ CD3− natural killer cells reflect the innate immune alterations of chronic HIV infection and support studies of immune surveillance, cytotoxicity, and antibody-dependent effector function.
NK Cells in HIV Infection
NK cells sit at the front line of innate antiviral defence, and HIV reshapes the compartment in specific, well-characterised ways:
- Expansion of an anergic CD56-negative subset — a dysfunctional population that accumulates in viremic donors and only partially resolves on therapy
- Impaired cytotoxicity and reduced degranulation, with altered activating and inhibitory receptor balance
- ADCC (antibody-dependent cellular cytotoxicity) — an effector mechanism strongly implicated as a correlate of protection in HIV vaccine trials, making donor NK cells directly relevant to vaccine research
- KIR/HLA interactions — specific combinations such as KIR3DS1 with HLA-Bw4 associate with slower disease progression, so genotype-stratified NK cells support host-genetics work
- Adaptive or memory-like NK expansion, particularly in CMV-coinfected donors
Donor Stratification Available
- Viral load and CD4+ count where tested
- Treatment status — viremic, or suppressed on ART with duration
- KIR and HLA genotype where sequenced
- CMV serostatus — relevant to adaptive NK subset frequency
- Elite controllers — available as custom collections
- Matched seronegative controls available
Product Features
- Research Use Only (RUO), CD56+ enriched NK cells
- Isolated from clinically diagnosed HIV-positive donors
- High viability and enrichment
- Cryopreserved in CryoStor® CS10 media
- Processed within 24 hours of collection
- Flow cytometry purity and viability data per lot
- Ethically sourced with IRB approval and HIPAA compliance
- Biosafety-compliant handling and shipping
De-identified Donor Data
- Confirmed diagnosis of HIV
- Demographics: age, sex assigned at birth, race/ethnicity
- Self-reported clinical history and medication use
Applications
- NK cell phenotype and function studies in HIV
- ADCC assays and vaccine correlate-of-protection research
- Cytotoxicity, degranulation, and immune exhaustion assays
- KIR/HLA host genetics research
- Adaptive and memory-like NK characterisation
- Single-cell analysis and receptor repertoire profiling
- Disease mechanism studies and biomarker identification
- Preclinical immunotherapy development, including CAR-NK approaches
Other HIV Specimen Types
Matched material is available as HIV CD3+ T cells, CD4+ T cells, CD8+ T cells, CD19+ B cells, PBMC, and leukopak.
Compliance and Quality Assurance
- IRB-approved collection and 21 CFR Part 11–compliant e-consent
- Standardized processing and quality protocols
- HIPAA-compliant data handling
Ordering & Customization
HIV CD56+ NK Cells are offered in standard or custom aliquot sizes. For pricing, regulatory documentation, or international support, contact learnmore@sanguinebio.com. For the full range, see our human CD56+ NK cells collection.
Protocols & Documentation
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Download
Immune Cell Isolation
Guidelines for isolating immune cell populations with validated enrichment steps, purity checkpoints, and documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Frequently Asked Questions
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YES – All collections are conducted under IRB-approved protocols and electronic informed consent. Sanguine utilizes Advarra and WCG IRB for oversight.
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YES – all our products are research use only (RUO).
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You can find our full product catalog here.
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Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
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Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
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Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
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Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
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YES – we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
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Each sample from a different individual – Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
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YES – Unique donors can be specified and guaranteed based on your requirements.
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For information about sample quality, please see: Quality and Compliance
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YES – “IRB-approved collection protocols” and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Ask a Question
Need a custom CD56+ NK Cells cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.