Sjogren’s Syndrome Serum

Human Sjögren’s Syndrome Serum for Autoimmune and Autoantibody Research

Our Sjögren’s Syndrome Serum is sourced from IRB-consented donors clinically diagnosed with Sjögren’s syndrome. Each sample is processed and frozen within 24 hours of collection to preserve autoantibodies, immunoglobulin fractions, cytokines, and complement components for autoimmune biomarker research.

Why Serum for Sjögren’s Syndrome Research

Sjögren’s syndrome is a genuine systemic autoimmune disease: lymphocytes infiltrate the exocrine glands, tolerance to self ribonucleoprotein antigens is lost, and B cell hyperactivity dominates the serological picture. Serum is collected without anticoagulant, which makes it the reference matrix for autoantibody and complement measurement.

• Defining autoantibodies — anti-Ro/SSA (against Ro52 and Ro60) and anti-La/SSB are the classification-level serological markers, and serum is the standard matrix in which they are detected and titred
• B cell hyperactivity is measurable in serum — polyclonal hypergammaglobulinaemia, rheumatoid factor positivity, elevated free light chains, and raised beta-2 microglobulin reflect the underlying B cell drive
• Type I interferon signature — interferon-inducible proteins and chemokines circulate in Sjögren’s and are targets for stratification and mechanism-of-action work
• B cell survival factors — BAFF and the germinal-centre chemokine CXCL13 reflect the ectopic lymphoid organisation seen in affected glands, giving serum a window on tissue-level pathology
• Lymphoma risk markers — low C4, cryoglobulins, and monoclonal components are recognised serological features associated with the elevated non-Hodgkin lymphoma risk in primary Sjögren’s, making serum relevant to risk-stratification research
• Primary versus secondary disease — secondary Sjögren’s overlapping rheumatoid arthritis or lupus carries an additional autoantibody profile, so specifying the classification is essential to cohort design

Donor Stratification Available

• Classification — primary Sjögren’s syndrome versus secondary Sjögren’s with an associated connective tissue disease
• Autoantibody profile — anti-Ro/SSA and anti-La/SSB status, ANA pattern, and rheumatoid factor where recorded
• Disease activity — ESSDAI or ESSPRI scores where documented
• Complement and immunoglobulin status — C3, C4, and total IgG reported per lot where measured
• Glandular and extraglandular involvement — sicca severity, salivary flow, arthritis, or pulmonary involvement where recorded
• Treatment status — untreated, hydroxychloroquine, corticosteroids, immunosuppressants, or B cell–directed therapy
• Matched healthy controls available — demographically matched healthy donor serum

Product Features

• Collected from clinically confirmed Sjögren’s syndrome donors
• Processed and frozen within 24 hours of collection
• Research Use Only (RUO)
• Standard and custom aliquot volumes available
• IRB-approved protocols with documented consent

De-identified Donor Data

• Diagnosis confirmation, including primary or secondary classification
• Age, sex assigned at birth, and ethnicity
• Donor-reported allergy, medication, and infectious disease history
• Autoantibody status, disease activity, and laboratory values available on request

Applications

• Anti-Ro/SSA and anti-La/SSB autoantibody detection and assay development
• Autoantibody profiling and serological classification research
• Type I interferon signature and interferon-inducible protein measurement
• BAFF, CXCL13, and B cell activation marker profiling
• Complement and immune complex studies
• Cytokine and inflammatory protein profiling
• Lymphoproliferation risk biomarker research
• Therapeutic candidate screening and treatment response stratification

Other Sjögren’s Syndrome Specimen Types

Matched material from the same Sjögren’s donor pool is available as Sjögren’s syndrome plasma, whole blood, PBMC, leukopak, and synovial fluid. Classification-specific cohorts are available as primary Sjögren’s syndrome serum and secondary Sjögren’s syndrome serum.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Sjögren’s syndrome serum is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse the full specimen range and healthy-donor controls, see our human serum collection.