Vitiligo Plasma

Vitiligo Plasma for Autoimmune Depigmentation Research

Vitiligo Plasma is collected from IRB-consented donors with a clinically confirmed diagnosis of vitiligo and processed within one day of collection to preserve labile analytes such as cytokines, chemokines, proteins and metabolites. Plasma is acellular, so it is supplied for soluble-analyte work — multiplex chemokine quantification, autoantibody serology, proteomics and metabolomics — in standard or custom aliquot volumes with de-identified clinical annotation.

Why Vitiligo Plasma for Autoimmune Research

Vitiligo is an autoimmune disease in which melanocytes are destroyed, producing well-demarcated depigmented macules. Melanocyte-specific CD8+ cytotoxic T cells are the principal effectors, recruited into skin by an interferon-gamma-driven chemokine axis. Although the effector cells act in the epidermis, the mediators that recruit and sustain them circulate, which makes plasma a genuinely mechanistic specimen for this disease rather than a generic inflammation matrix.

• Interferon-gamma-induced chemokines — CXCL9 and CXCL10 are the best-characterised soluble mediators in vitiligo, recruiting CXCR3-positive cytotoxic T cells to the skin, and they track with disease activity.
• The IFN-γ/JAK/STAT axis — this pathway is the mechanistic rationale for JAK inhibition in vitiligo, and its circulating outputs are directly measurable in plasma.
• Melanocyte antigen autoantibodies — antibodies against tyrosinase, TYRP1 and other melanocyte differentiation antigens are detectable in the acellular compartment.
• Oxidative stress mediators — melanocytes carry a high intrinsic oxidative burden from melanin synthesis, and markers of redox stress and damage-associated molecular patterns link cellular stress to immune activation.
• Associated autoimmune serology — vitiligo commonly co-occurs with other autoimmune conditions, and thyroid and related autoantibodies can be measured in the same sample.
• Acellular by design — plasma is the right input for immunoassay, multiplex and mass spectrometry workflows; melanocyte-specific T cell assays require a cellular product instead.

Donor Stratification Available

• Clinical subtype — non-segmental (generalised) vitiligo, segmental vitiligo, acrofacial, and universal disease
• Disease activity — actively spreading or unstable disease versus stable disease at the time of draw
• Extent of involvement — limited versus extensive body surface area affected, where documented
• Associated autoimmunity — donors with concurrent autoimmune thyroid disease, type 1 diabetes, alopecia areata, or pernicious anaemia
• Treatment status — treatment-naive, topical corticosteroid or calcineurin inhibitor, phototherapy, or JAK inhibitor-treated donors; Fitzpatrick skin type available on request
• Matched healthy controls available, drawn on the same protocol and matched for age, sex and ethnicity

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed vitiligo donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request
• Volumes and anticoagulant options reported per lot

De-identified Donor Data

• Verified vitiligo diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Subtype, activity and treatment context reported per lot where captured
• Additional vitiligo-specific metadata available on request

Applications

• CXCL9 and CXCL10 quantification and disease-activity biomarker qualification
• Interferon-gamma pathway output profiling for JAK inhibitor programmes
• Melanocyte antigen autoantibody detection and serology development
• Multiplex cytokine and chemokine profiling in active versus stable disease
• Oxidative stress and damage-associated molecular pattern marker studies
• Associated autoimmune serology screening within vitiligo cohorts
• Plasma proteomic and metabolomic discovery in autoimmune depigmentation
• Therapeutic pharmacodynamic and target engagement readout development

Other Vitiligo Specimen Types

• Vitiligo Serum
• Vitiligo PBMC
• Vitiligo Whole Blood
• Vitiligo Leukopak
• Vitiligo Skin Punch Biopsy

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11-compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Vitiligo plasma is available in standard and custom volumes. For pricing, international orders or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To compare collection formats or check wider availability, visit our human plasma page.