Graves’ Disease Plasma

About Graves’ Disease Plasma

Graves’ Disease Plasma for Autoimmune Thyroid Disease Research

Graves’ Disease Plasma is collected from IRB-consented donors clinically diagnosed with Graves’ disease and processed within one day of collection to preserve autoantibodies, hormones, cytokines, proteins, and metabolites. Graves’ disease is an autoimmune thyroid disorder caused by stimulating autoantibodies against the thyrotropin (TSH) receptor, which mimic TSH, drive unregulated thyroid hormone production, and cause hyperthyroidism with diffuse goitre. Plasma is acellular and is intended for soluble-analyte measurement rather than cell-based assays.

Disease Biology and Why Plasma

• TSH receptor autoantibodies (TRAb) are the direct cause of disease. Unusually among autoimmune conditions, the pathogenic antibody is stimulating rather than blocking or destructive, making Graves’ a reference model for agonist autoantibody biology.
• Functional assay substrate: thyroid-stimulating immunoglobulin (TSI) bioassays and TSH-binding inhibitory immunoglobulin (TBII) assays both use circulating antibody and require acellular donor material.
• Additional thyroid autoantibodies — anti-thyroid peroxidase (TPO) and anti-thyroglobulin — are frequently present and useful for distinguishing and overlapping with Hashimoto’s thyroiditis.
• Thyroid function analytes: TSH, free T4 and free T3 can be measured from the same aliquot, allowing antibody titre to be related to hormonal status.
• Thyroid eye disease: a substantial subset of donors develop orbitopathy driven by TSH receptor and IGF-1 receptor signalling in orbital fibroblasts, the target of newer biologic therapy.
• Cytokine and immune profiling supports work on the Th1/Th2/Th17 balance and B-cell help underpinning autoantibody production.

Donor Stratification Available

• TSH receptor antibody status and titre where available
• Additional autoantibody positivity: anti-TPO, anti-thyroglobulin
• Biochemical status at collection: overt hyperthyroid, subclinical, or euthyroid on treatment
• Presence and activity of thyroid eye disease / Graves’ orbitopathy
• Treatment status: antithyroid drugs (methimazole, propylthiouracil), radioiodine therapy, post-thyroidectomy, biologic therapy for orbitopathy, or treatment-naive
• Coexisting autoimmune conditions such as type 1 diabetes, vitiligo, or coeliac disease
• Matched healthy controls available

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed Graves’ disease donors
• Processed within one day of collection
• Anticoagulant selection available on request
• IRB-approved protocols and informed consent
• Custom aliquot volumes available upon request

De-identified Donor Data

• Verified Graves’ disease diagnosis
• Thyroid function and autoantibody results where available
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Additional Graves’ disease-specific metadata available

Applications

• TSH receptor autoantibody detection, titration, and stimulating versus blocking characterisation
• TSI bioassay and TBII assay development and validation
• Anti-TPO and anti-thyroglobulin autoantibody profiling
• Thyroid hormone and TSH immunoassay development
• Thyroid eye disease biomarker research, including IGF-1 receptor pathway work
• Cytokine and inflammation profiling
• Proteomic and metabolomic biomarker discovery
• Therapeutic response and relapse-prediction research

Other Graves’ Disease Specimen Types

Graves’ disease donor material is also available as Graves’ Disease Serum, Graves’ Disease PBMC, Graves’ Disease Whole Blood, Graves’ Disease Leukopak, and Graves’ Disease Bulk Plasma. Related cohorts include Thyroid Eye Disease Plasma and Hyperthyroidism Serum.

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Graves’ disease plasma is available in standard and custom volumes. For pricing, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. For the full specimen range, see our human plasma collection.