Rheumatoid Arthritis Plasma

Rheumatoid Arthritis Plasma for Autoimmune and Inflammation Research

Rheumatoid Arthritis Plasma is collected from IRB-consented donors clinically diagnosed with rheumatoid arthritis (RA) and processed within one day of collection to preserve labile analytes such as cytokines, proteins, and metabolites. Anticoagulant type and aliquot volume are configured per project and reported per lot. This plasma supports research into autoimmune and inflammatory biomarkers, acute phase proteins including CRP, and methods for predicting flares. Bulk plasma is available.

Why Plasma for Rheumatoid Arthritis Research

Rheumatoid arthritis is a systemic autoimmune disease. Although the joint is the principal target, the autoantibody response and the acute phase reaction are systemic, which is why circulating specimens carry genuine diagnostic and mechanistic information rather than being a proxy for the joint.

• Anti-citrullinated protein antibodies and rheumatoid factor are the defining serological markers of RA, and their presence separates seropositive from seronegative disease — groups that differ in prognosis and in erosive potential.
• ACPA can be detectable years before clinical arthritis develops, which makes circulating specimens the only practical material for research into the pre-clinical and at-risk phases of the disease.
• Citrullination by peptidylarginine deiminase enzymes generates the neoepitopes recognised by ACPA, and antibodies to these modified proteins are measurable in plasma.
• The systemic acute phase response — CRP and related proteins — is part of the formal disease activity assessment in RA, so plasma analytes map directly onto composite clinical scores.
• TNF, IL-6, and GM-CSF are established therapeutic targets in RA, and plasma allows the systemic component of these pathways to be measured before and after treatment.
• Because plasma is collected without a clotting step, it preserves coagulation-sensitive mediators and is the preferred matrix on many proteomic and multiplex cytokine platforms; paired serum and synovial fluid from the same donor allow systemic and joint compartments to be compared.

Donor Stratification Available

• Serological status: ACPA and rheumatoid factor positive or negative, with titre where documented
• Disease activity: composite score such as DAS28 or CDAI, and CRP or ESR band where recorded
• Disease duration: early versus established RA, and erosive versus non-erosive disease
• Treatment status: DMARD-naive, methotrexate or other conventional DMARD, TNF inhibitor, IL-6 receptor inhibitor, T cell costimulation blockade, anti-CD20, or JAK inhibitor
• Extra-articular manifestations where documented, including nodules and interstitial lung disease
• Smoking status, a well-established RA risk factor that interacts with genetic risk and ACPA positivity
• Matched healthy controls available, alongside comparator inflammatory arthritis cohorts

Product Features

• Research Use Only (RUO)
• Plasma collected from clinically confirmed RA donors
• Processed within one day of collection
• IRB-approved protocols and informed consent
• Anticoagulant type specified at order where inventory permits
• Custom aliquot volumes available upon request
• Volumes and lot-specific processing details reported per lot

De-identified Donor Data

• Verified RA diagnosis
• Demographic data: age, sex assigned at birth, race/ethnicity
• Donor-reported medications, allergies, and comorbidities
• Serology and disease activity data where available
• Additional RA-specific metadata available on request

Applications

• ACPA and rheumatoid factor assay development, calibration, and specificity testing
• Biomarker discovery and validation for disease activity and flare prediction
• Cytokine and inflammation profiling, including TNF and IL-6 pathway readouts
• Acute phase protein and complement analysis
• Proteomic and metabolomic characterisation of systemic autoimmune inflammation
• Treatment-response and pharmacodynamic research across biologic and JAK inhibitor classes
• Autoantibody repertoire and citrullinated antigen reactivity profiling
• Comparative studies against seronegative inflammatory arthritis and osteoarthritis cohorts

Other Rheumatoid Arthritis Specimen Types

• Rheumatoid Arthritis Serum
• Rheumatoid Arthritis Whole Blood
• Rheumatoid Arthritis PBMC
• Rheumatoid Arthritis Leukopak
• Rheumatoid Arthritis Synovial Fluid
• Rheumatoid Arthritis Bulk Plasma

Compliance and Quality Assurance

• IRB-approved and HIPAA-compliant protocols
• Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
• Documentation support available for regulatory review

Ordering & Customization

Rheumatoid arthritis plasma is available in standard and custom volumes. For pricing, availability, international orders, or documentation requirements, please email learnmore@sanguinebio.com to ensure compatibility with your country’s regulations. To browse other disease states and collection formats, visit our human plasma page.