Systemic Lupus Erythematosus Serum
Powered by BiozAbout:Systemic Lupus Erythematosus Serum from IRB-consented donors with clinically confirmed SLE, processed and frozen within 24 hours of collection. Serum is the classical matrix for lupus autoantibody serology (ANA, anti-dsDNA, anti-Sm, anti-Ro/SSA, anti-RNP), complement C3 and C4 consumption, type I interferon signature markers and BAFF. Donors can be stratified by autoantibody profile, complement status, disease activity, organ involvement and treatment, with matched healthy controls available.
About Systemic Lupus Erythematosus Serum
Systemic Lupus Erythematosus Serum for Autoimmune and Autoantibody Research
Our Systemic Lupus Erythematosus Serum is sourced from IRB-consented donors clinically diagnosed with systemic lupus erythematosus (SLE). Each sample is processed and frozen within 24 hours of collection to ensure consistency and high quality for autoimmunity, autoantibody and inflammation research. SLE is a prototypical systemic autoimmune disease characterised by loss of tolerance to nuclear antigens, immune complex deposition and a type I interferon-driven inflammatory response.
Why Serum for Systemic Lupus Erythematosus Research
- Serum is the classical matrix for lupus serology. Antinuclear antibodies are near-universal, and the clinically informative specificities, including anti-double-stranded DNA, anti-Sm, anti-Ro/SSA, anti-La/SSB, anti-RNP and antiphospholipid antibodies, are all measured in serum.
- Anti-dsDNA titre and complement consumption move with disease activity. Because C3 and C4 are consumed by immune complex-driven classical pathway activation, low C3 and C4 in serum are a direct readout of active immune complex disease, and disease-state serum is essential for developing assays that track it.
- SLE carries a well-characterised type I interferon signature, and serum supports quantification of interferon-inducible proteins and downstream chemokines. This pathway is the target of interferon receptor blockade, making interferon-related serum markers directly relevant to current drug development.
- B-cell survival factor BAFF/BLyS is elevated in SLE serum and is the target of an approved biologic, so serum from treated and untreated donors supports pharmacodynamic and target-engagement assay work.
- SLE is heterogeneous across organ domains. Serum from donors annotated by renal, cutaneous, articular, haematologic and neuropsychiatric involvement lets researchers link circulating markers to specific disease manifestations rather than to a single global label.
- Serum removes fibrinogen and most clotting factors and is the matrix on which most commercial autoimmune serology kits are validated; matched SLE plasma is available where coagulation-sensitive or complement-activation analytes are the target.
Donor Stratification Available
- Autoantibody profile where documented: ANA pattern and titre, anti-dsDNA, anti-Sm, anti-Ro/SSA, anti-La/SSB, anti-RNP, antiphospholipid antibodies
- Complement status where documented, including low versus normal C3 and C4
- Disease activity, including active flare versus quiescent disease, with SLEDAI where documented
- Organ involvement: lupus nephritis, cutaneous, articular, haematologic, serositis or neuropsychiatric
- Treatment status: hydroxychloroquine, corticosteroid, mycophenolate or other immunosuppressant, anti-BAFF or anti-interferon receptor biologic
- Matched healthy controls available, along with related autoimmune donors such as Sjogren’s syndrome and cutaneous lupus for comparison
Product Features
- Collected from clinically confirmed lupus donors
- Research Use Only (RUO)
- Processed and frozen within 24 hours of collection
- IRB-approved protocols with documented consent
- Standard and custom aliquot volumes; volumes reported per lot
- Matched plasma, whole blood, PBMC and isolated immune cell fractions available on request
De-identified Donor Data
- Confirmed SLE diagnosis by physician or specialist
- Demographic details: age, sex assigned at birth, ethnicity
- Medical history including allergies and infectious disease status
- Serology, organ involvement and treatment detail available on request
- Explore our SLE Donor Network
Applications
- Autoantibody assay development and validation, including anti-dsDNA and extractable nuclear antigen panels
- Complement C3 and C4 quantification and immune complex research
- Type I interferon signature and interferon-inducible protein profiling
- BAFF/BLyS and B-cell axis biomarker research
- Serum cytokine and chemokine profiling
- Disease activity and flare-prediction biomarker discovery
- Serum proteomics and metabolomics
- Therapeutic candidate screening, target validation and pharmacodynamic assay development
Other Systemic Lupus Erythematosus Specimen Types
- Systemic Lupus Erythematosus Plasma
- Systemic Lupus Erythematosus Whole Blood
- Systemic Lupus Erythematosus PBMC
- Systemic Lupus Erythematosus Leukopak
- Systemic Lupus Erythematosus Bulk Plasma
- Systemic Lupus Erythematosus CD19+ B Cells
- Lupus (SLE) Skin Punch Biopsy
- Lupus Nephritis Serum
Compliance and Quality Assurance
- IRB-approved and HIPAA-compliant protocols
- Electronic informed consent with 21 CFR Part 11 – compliant e-signatures
- Documentation support available for regulatory review
Ordering & Customization
Systemic lupus erythematosus serum is available in standard and custom volumes. For pricing, current availability, or a quote on a stratified donor cohort, email learnmore@sanguinebio.com. For international orders or documentation requirements, please contact us to ensure compatibility with your country’s regulations. To browse other disease states in this specimen type, visit our human serum page.
Donor Metadata
- Verified diagnosis and clinical history
- Demographic data: age, sex assigned at birth, race/ethnicity
- Medication and treatment background when available
Compliance and Quality Assurance
- IRB-approved collections and standardized procedures
- 21 CFR Part 11-compliant e-consent system
- HIPAA-compliant data management
Ordering & Customization
Human Serum are available in customizable aliquot sizes. For international orders or documentation needs, please contact learnmore@sanguinebio.com to confirm requirements and availability. We also work with multiple ordering platforms and distributors, learn more here.
Protocols & Documentation
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Download
Serum Isolation
Protocol for serum preparation from whole blood, including collection handling, clarification, and quality documentation.
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Informed Consent Form (ICF)
Available upon request — confirms donor consent for research use and downstream commercialization.
Serum
Where can I find your complete catalog?
You can find our full product catalog here.
How long can samples be stored?
Storage depends on sample type but often cryopreserved samples stored in liquid nitrogen can be stored for years.
What customization options are available?
Extensive customization is available. To discuss your project request a quote or email us at learnmore@sanguinebio.com.
Do you offer prospective collections?
Sanguine offers flexible prospective collection services tailored to fit your research. For more information and to request a quote, please see: our prospective biospecimen collection services page.
What is the turnaround time for custom collections?
Timelines depend on condition, sample type, and I/E criteria but we often start collection within 2 weeks of signed agreement.
Do you have samples in stock?
YES - we have in-stock inventory. You can also email us at learnmore@sanguinebio.com as we continually get new samples in our inventory.
What does unique donor mean?
Each sample from a different individual - Unique donor means each sample comes from a different person, ensuring biological diversity in your study.
Are samples collected under IRB-approved protocols?
YES - "IRB-approved collection protocols" and IRB approval documentation available upon request. Sanguine utilizes two internationally-recognized IRBs (Advarra and WCG IRB) for review and approval.
Frequently Asked Questions
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100 In Stock View InventoryNeed a custom Serum cohort?
Our scientific team can scope prospective collections with donor-specific I/E criteria, typically starting within 2 weeks of agreement.